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// RUN — FITS
Can the AMD Instinct MI300X 192GB run MedGemma 27B?
Yes — here's how fast and up to what context, with real measured numbers.
MedGemma 27B on the AMD Instinct MI300X 192GB
| Quant | Fits? | Max context | Speed | Beyond context |
|---|---|---|---|---|
| FP16 | yes | 462k | 61.8-75.6 t/s | ~0.5-0.6 (slow) |
| Q8 | yes | 565k | 123.7-151.1 t/s | ~0.9-1.1 (slow) |
| Q4 | yes | 610k | 220.8-269.9 t/s | ~1.7-2 (slow) |
Estimate (memory-bound). Beyond "max context" the KV cache spills to system RAM offload (depends on your system RAM) and speed drops to the "beyond" figure.
FAQ
Can the AMD Instinct MI300X 192GB run MedGemma 27B?▶
Yes. At Q4 it generates ~220.8-269.9 tok/s and fits up to 610k context; beyond that it spills to system RAM offload (depends on your system RAM) and slows to ~1.7-2 tok/s.
How much context fits?▶
At Q4, up to about 610k tokens stay in fast memory; longer context spills to system RAM offload (depends on your system RAM) and throughput collapses.