// RUN โ€” FITS

Can the NVIDIA GeForce RTX 4090 run ProtT5-XXL?

Yes โ€” here's how fast and up to what context, with real measured numbers.

ProtT5-XXL on the NVIDIA GeForce RTX 4090

QuantFits?Max contextSpeedBeyond context
FP16 no โ€” โ€” โ€”
Q8 yes 58k 66.9-79.7 t/s ~2.7-3.2 (slow)
Q4 yes 88k 119.5-142.4 t/s ~4.7-5.6 (slow)

Estimate (memory-bound). Beyond "max context" the KV cache spills to system RAM offload (depends on your system RAM) and speed drops to the "beyond" figure.

FAQ

Can the NVIDIA GeForce RTX 4090 run ProtT5-XXL?โ–ถ

Yes. At Q4 it generates ~119.5-142.4 tok/s and fits up to 88k context; beyond that it spills to system RAM offload (depends on your system RAM) and slows to ~4.7-5.6 tok/s.

How much context fits?โ–ถ

At Q4, up to about 88k tokens stay in fast memory; longer context spills to system RAM offload (depends on your system RAM) and throughput collapses.