// RUN โ€” FITS

Can the NVIDIA RTX 6000 Ada 48GB run SimpleFold?

Yes โ€” here's how fast and up to what context, with real measured numbers.

SimpleFold on the NVIDIA RTX 6000 Ada 48GB

QuantFits?Max contextSpeedBeyond context
FP16 yes 559k 116.8-139.2 t/s ~4.9-5.8 (slow)
Q8 yes 605k 233.6-278.4 t/s ~9.7-11.6 (slow)
Q4 yes 625k 417.1-497.1 t/s ~17.4-20.7 (slow)

Estimate (memory-bound). Beyond "max context" the KV cache spills to system RAM offload (depends on your system RAM) and speed drops to the "beyond" figure.

FAQ

Can the NVIDIA RTX 6000 Ada 48GB run SimpleFold?โ–ถ

Yes. At Q4 it generates ~417.1-497.1 tok/s and fits up to 625k context; beyond that it spills to system RAM offload (depends on your system RAM) and slows to ~17.4-20.7 tok/s.

How much context fits?โ–ถ

At Q4, up to about 625k tokens stay in fast memory; longer context spills to system RAM offload (depends on your system RAM) and throughput collapses.